Replication Stress Response
Gene co-expression module in Hematopoietic progenitor cells
| Category | Cell cycle |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include DNAJC9 (chaperone involved in replication stress), HLTF (E3 ubiquitin ligase for DNA damage tolerance/replication fork stability), CENPU (centromere protein, kinetochore assembly), WEE1 (G2/M checkpoint kinase), POLE2 (DNA polymerase epsilon subunit, replication), and EIF2AK1 (stress kinase, heme-regulated). YARS1 is an aminoacyl-tRNA synthetase. MRPL52 is mitochondrial ribosomal. The combination of replication stress response (HLTF, DNAJC9), cell cycle checkpoint (WEE1, CENPU), and DNA synthesis (POLE2) strongly points to S/G2 phase DNA damage response and replication stress. The module is uniformly expressed across HPC subsets at low levels, consistent with a cell cycle-associated program active in cycling progenitors. Neighbor modules (M41, M38, M8) are also broadly expressed, supporting a general proliferative/housekeeping context.
Genes
CENPU, DNAJC9, EIF2AK1, HLTF, MRPL52, PIP4K2A, POLE2, SLC12A6, TLN1, WEE1, YARS1
Most correlated modules
- Chromatin Remodeling · correlation 0.90
- Erythroid Progenitor Program · correlation 0.89
- Erythroid Differentiation · correlation 0.86
- Erythro-Megakaryocytic Development · correlation 0.82
- HSC Progenitor Proliferation · correlation 0.82
- Oxidative Stress Survival · correlation 0.82
- Hematopoietic Progenitor Identity · correlation 0.82
- General Metabolic Housekeeping · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.