SLC12A6 — Solute carrier family 12 member 6
SLC12A6 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC12A6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | TGF-beta/differentiation Intercellular communication | CDC42SE1, CEMIP2, ENC1, KLF3, LYST, SMAD3, ST3GAL1, TSPAN3 | View in SCUBA |
| CD4⁺ T cells | IL10/cytokine signaling Immune regulation | CASK, CCDC141, FOXN3, IL10RA, IL7, STAMBPL1, TMEM154, TNFRSF13B +4 more | View in SCUBA |
| Gamma-delta T cells | Gut-homing Residence Tissue residence | ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DAPK2 +8 more | |
| Hematopoietic progenitor cells | Replication Stress Response Cell cycle | CENPU, DNAJC9, EIF2AK1, HLTF, MRPL52, PIP4K2A, POLE2, TLN1 +2 more | |
| Macrophages | Hypoxia-driven Activation Inflammatory | ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more | View in SCUBA |
| Neutrophils | Endosomal Vesicle Trafficking Vesicular traficking | DIP2B, ELF2, JAK1, NRDC, OSBPL8, PCNX1, PICALM, TBXAS1 +3 more |
About the gene
| Synonyms | ACCPN, KCC3, KCC3A, KCC3B |
|---|---|
| Chromosome | 15: 34229784-34338060 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Potassium transport, Symport, Transport |
Function
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable). Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable). Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable). Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable). Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.