POLG2 — DNA polymerase gamma 2, accessory subunit
POLG2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLG2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Chromatin Transcriptional Regulation Developmental | BRD2, C6orf62, CBX4, GLS, KLHL15, LSMEM1, MKNK2, NUFIP2 +4 more | View in SCUBA |
About the gene
| Synonyms | HP55, MTPOLB |
|---|---|
| Chromosome | 17: 64477785-64497054 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA replication |
Function
Accessory subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Acts as an allosteric regulator of the holoenzyme activities. Enhances the polymerase activity and the processivity of POLG by increasing its interactions with the DNA template. Suppresses POLG exonucleolytic proofreading especially toward homopolymeric templates bearing mismatched termini. Binds to single-stranded DNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.