Chromatin Transcriptional Regulation
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include CBX4 (Polycomb chromatin repressor), BRD2 (bromodomain chromatin reader), SIRT1 (NAD-dependent deacetylase with chromatin and metabolic roles), POLR2A (RNA Pol II large subunit), NXF1 (nuclear RNA export factor), NUFIP2 (RNA binding), and MKNK2 (translation regulation). GLS (glutaminase) and POLG2 (mitochondrial DNA polymerase) add metabolic dimensions. The module reflects coupled epigenetic/chromatin regulation and transcriptional activity, consistent with a transcriptionally active but epigenetically regulated fibroblast substate. Low expression (14.4% positive) suggests a minority subpopulation.
Genes
BRD2, C6orf62, CBX4, GLS, KLHL15, LSMEM1, MKNK2, NUFIP2, NXF1, POLG2, POLR2A, SIRT1, TENT5C
Most correlated modules
- Co-transcriptional RNA Processing · correlation 0.93
- Hypoxia-driven EMT · correlation 0.93
- Unfolded Protein Response · correlation 0.90
- Heat Shock Response · correlation 0.85
- Fibroblast Quiescence · correlation 0.81
- Type I Interferon · correlation 0.78
- Integrated Stress Response · correlation 0.78
- Proteotoxic Stress Survival · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.