CAT — Catalase
CAT belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Colonocyte Metabolic Defense Mitochondrial & OxPhos | ACAA2, CRYBG1, GLIPR2, MLXIP, PKDCC, SAMD5, SEMA6A, ZFHX3 | View in SCUBA |
| Innate lymphoid cells | NK Activating Receptors Cytotoxicity | CRACDL, ELAPOR1, FLT3LG, KLRK1, KRTCAP2, LTA4H, MFSD10, MLLT3 +7 more | View in SCUBA |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CD4, CHID1 +26 more | View in SCUBA |
About the gene
| Chromosome | 11: 34438934-34472060 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Mitogen, Oxidoreductase, Peroxidase |
| Biological process | Hydrogen peroxide |
Function
Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.