BDH2 — 3-hydroxybutyrate dehydrogenase 2
BDH2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BDH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Lipid Redox Homeostasis Housekeeping | ADH5, CASP6, DECR1, LAPTM4B, LGALS9, PAFAH1B3, THYN1, UBE2E3 | View in SCUBA |
About the gene
| Synonyms | DHRS6, FLJ13261, PRO20933, SDR15C1, UCPA-OR, UNQ6308 |
|---|---|
| Chromosome | 4: 103077592-103099870 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
| Biological process | Lipid metabolism |
Function
NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L- proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (By similarity). May act as a 3-hydroxybutyrate dehydrogenase.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.