CMBL — Carboxymethylenebutenolidase homolog
CMBL belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CMBL's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCL7C, BLCAP, C20orf204, CTDSPL, DDB2, FLRT2, ITM2C, KLHL4 +11 more | View in SCUBA |
| Enterocytes | Carbohydrate Digestion/Detox Nutrient metabolism | CBR1, DDC, GSTA1, HADHB, KBTBD11, MAOA, PEBP1, SI +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Glycolysis Erythropoietic | ENO1, GAPDH, GYPC, LMO2, LY6E, MAP7, NENF, PKM +3 more |
About the gene
| Synonyms | FLJ23617 |
|---|---|
| Chromosome | 5: 10275875-10307902 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.