POLR2M — RNA polymerase II subunit M
POLR2M belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
POLR2M's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Mucosal-associated invariant T cell | Transcription Factor Activity DNA/chromatin regulation | AKAP17A, BTAF1, HNRNPH1, HSPA9, IKZF5, LCOR, NDEL1, SDE2 +3 more |
About the gene
| Synonyms | Gdown, Gdown1, GRINL1A |
|---|---|
| Chromosome | 15: 57706695-57782762 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, RNA polymerase related proteins |
| Biological process | Transcription |
Function
Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.