SDE2 — SDE2 telomere maintenance homolog

SDE2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SDE2's module in each cell type

Cell type	Module	Shares the module with
Endothelial	Glucocorticoid Response Endothelial cell development	APOLD1, DENND3, DPYSL2, JAM3, KLF11, KLF9, MFSD6, NDRG1 +8 more	View in SCUBA
Gamma-delta T cells	Transcription-RNA Coupling DNA/chromatin regulation	AKNA, AP1G1, BTAF1, BZW1, CRNKL1, DDX6, DNTTIP2, DYNC1H1 +26 more
Mucosal-associated invariant T cell	Transcription Factor Activity DNA/chromatin regulation	AKAP17A, BTAF1, HNRNPH1, HSPA9, IKZF5, LCOR, NDEL1, POLR2M +3 more

About the gene

Synonyms	C1orf55, FLJ35382
Chromosome	1: 225982702-225999343
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	DNA-binding, RNA-binding
Biological process	Cell cycle, Cell division, DNA replication, Mitosis, mRNA processing, mRNA splicing, Ribosome biogenesis

Function

Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage. Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome (By similarity). Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.