Transcription Factor Activity
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes IKZF5 (Ikaros-family transcription factor), BTAF1 (TAF1-related transcription regulator), ZNF207 (zinc finger transcription factor), LCOR (ligand-dependent nuclear receptor corepressor), POLR2M (RNA pol II small subunit), HNRNPH1 and SRRM2 (RNA splicing/processing), and ZPR1 (zinc finger protein involved in rRNA processing and RNA pol II regulation) collectively define a transcriptional regulation and RNA processing program. NDEL1 is a cytoskeletal regulator typically linked to cell division. HSPA9 is a mitochondrial chaperone. SDE2 links to replication stress/DNA damage. Strong coherence with a dominant theme of transcription factor activity and RNA processing.
Genes
AKAP17A, BTAF1, HNRNPH1, HSPA9, IKZF5, LCOR, NDEL1, POLR2M, SDE2, SRRM2, ZNF207, ZPR1
Most correlated modules
- Co-transcriptional Splicing · correlation 0.88
- Post-translational Regulation · correlation 0.85
- Cytoskeletal Organization · correlation 0.84
- Autophagy & Trafficking · correlation 0.84
- Stress Granule Response · correlation 0.83
- mRNA 3' Processing · correlation 0.82
- AP-1/MEF2 Activation · correlation 0.80
- Nuclear-Cytoplasmic Transport · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.