RAD54L — RAD54 like
RAD54L belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAD54L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | G2/M Checkpoint Cell cycle | CCDC34, CDCA4, CDCA5, MND1, MYBL2, OIP5, RRM2, SAC3D1 +1 more | View in SCUBA |
About the gene
| Synonyms | hHR54, hRAD54, RAD54A |
|---|---|
| Chromosome | 1: 46246461-46278480 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding, Helicase, Hydrolase |
| Biological process | DNA damage, DNA repair |
Function
Plays an essential role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.