RRM2 — Ribonucleotide reductase regulatory subunit M2
RRM2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RRM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ACTL6A, LMNB1, SAE1, SMC2, SSRP1, TFDP1, TYMS, UBE2T +2 more | View in SCUBA |
| CD8⁺ T cells | G2/M Checkpoint Cell cycle | CCDC34, CDCA4, CDCA5, MND1, MYBL2, OIP5, RAD54L, SAC3D1 +1 more | View in SCUBA |
| Gamma-delta T cells | Mitosis Execution Cell cycle | ASF1B, BUB1, CDCA8, CENPE, CENPF, CKS1B, EZH2, MAD2L1 +12 more | |
| Goblet cells | FOXM1-driven G2/M Cell cycle | CDCA5, CENPK, DIAPH3, E2F8, ESCO2, FOXM1, IQGAP3, MELK +5 more | View in SCUBA |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
| Natural Killer cells | S-phase Replication Cell cycle | CDT1, CENPM, CENPU, CLSPN, FANCI, PCLAF, TYMS | View in SCUBA |
| Neutrophils | S-G2-M Cell Cycle Cell cycle | ATAD2, CENPP, CNTRL, EZH2, LNPEP, MIS18BP1, SMC4, TOPBP1 +1 more |
About the gene
| Synonyms | C2orf48, FLJ25102 |
|---|---|
| Chromosome | 2: 10120698-10211725 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Deoxyribonucleotide synthesis |
Function
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.