G2/M Checkpoint
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
RRM2 (ribonucleotide reductase R2, rate-limiting for dNTP synthesis in S-phase), CDCA5 (sororin, cohesin regulation in S/G2), CDCA4 (E2F-associated, S-phase), MYBL2 (B-Myb, G2/M transcription factor), TRIP13 (AAA-ATPase, spindle assembly checkpoint), MND1 (meiotic/mitotic recombination), RAD54L (DNA repair/recombination), OIP5 (kinetochore, Mis18BP1), SAC3D1 (centrosome/mitosis), CCDC34 (centrosome-associated). The module centers on late S-phase and G2/M with emphasis on DNA replication fidelity, recombination, and spindle checkpoint. Lower mean expression and pct positive (~4%) suggest a more restricted cycling subpopulation. Neighbor context: complements M86/M40/M82 as another arm of the cell cycle program, here focused on G2/M transition.
Genes
CCDC34, CDCA4, CDCA5, MND1, MYBL2, OIP5, RAD54L, RRM2, SAC3D1, TRIP13
Most correlated modules
- Mitotic Spindle Assembly · correlation 0.97
- Mitotic Spindle · correlation 0.96
- S-phase Progression · correlation 0.95
- Replication Licensing · correlation 0.95
- FOXM1-driven G2/M · correlation 0.91
- CDK1-Aurora Kinase Mitosis · correlation 0.90
- Replication Stress Checkpoint · correlation 0.88
- Mitosis & Cytokinesis · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.