CDCA5 — Cell division cycle associated 5
CDCA5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDCA5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Replication Licensing Cell cycle | ASF1B, CDC6, CDT1, CENPK, CENPU, CLSPN, DNAJC9, FAM111B +5 more | View in SCUBA |
| CD8⁺ T cells | G2/M Checkpoint Cell cycle | CCDC34, CDCA4, MND1, MYBL2, OIP5, RAD54L, RRM2, SAC3D1 +1 more | View in SCUBA |
| Goblet cells | FOXM1-driven G2/M Cell cycle | CENPK, DIAPH3, E2F8, ESCO2, FOXM1, IQGAP3, MELK, ORC6 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Late S-phase G2 Entry Cell cycle | ASF1B, CDC45, CENPM, DIAPH3, MND1, MYBL2, PKMYT1, RAD51AP1 +1 more |
About the gene
| Chromosome | 11: 65066300-65084164 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.