MND1 — Meiotic nuclear divisions 1
MND1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MND1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle G1/S Cell cycle | CARHSP1, CBX5, CENPM, DNMT1, GMNN, HMGB2, HMGN2, MYBL2 +8 more | View in SCUBA |
| CD8⁺ T cells | G2/M Checkpoint Cell cycle | CCDC34, CDCA4, CDCA5, MYBL2, OIP5, RAD54L, RRM2, SAC3D1 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Late S-phase G2 Entry Cell cycle | ASF1B, CDC45, CDCA5, CENPM, DIAPH3, MYBL2, PKMYT1, RAD51AP1 +1 more |
About the gene
| Synonyms | GAJ |
|---|---|
| Chromosome | 4: 153344649-153415118 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA recombination, Meiosis |
Function
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double- strand breaks.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.