RFXANK — Regulatory factor X associated ankyrin containing protein
RFXANK belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RFXANK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | p53 Stress Response Stress | BACE2, COPS9, NT5C, OST4, PDLIM1, PGLS, POLR2L, SEM1 +1 more | View in SCUBA |
About the gene
| Synonyms | ANKRA1, BLS, F14150_1, MGC138628, RFX-B |
|---|---|
| Chromosome | 19: 19192229-19201869 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. May also potentiate the activation of RAF1 (By similarity). Isoform 2 is not involved in the positive regulation of MHC class II genes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.