NT5C — 5', 3'-nucleotidase, cytosolic
NT5C belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NT5C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | p53 Stress Response Stress | BACE2, COPS9, OST4, PDLIM1, PGLS, POLR2L, RFXANK, SEM1 +1 more | View in SCUBA |
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA3, COA4, COMMD8, GALK1, GEMIN6 +24 more | |
| Mucosal-associated invariant T cell | RNA Biogenesis & Folding Housekeeping | ADH5, CCT3, CTDSP1, FAM117A, FKBP1A, FKBP8, LSM4, MAT2B +6 more |
About the gene
| Synonyms | cdN, DNT-1, DNT1, PN-I, UMPH2 |
|---|---|
| Chromosome | 17: 75130225-75131757 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Nucleotide metabolism |
Function
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.