p53 Stress Response
Gene co-expression module in Endothelial
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes include TP53I3 (p53-inducible gene 3, oxidoreductase/p53 target), OST4 (oligosaccharyltransferase subunit, N-glycosylation in ER), POLR2L (RNA polymerase II subunit), PDLIM1 (PDZ-LIM domain protein, cytoskeletal), SEM1 (26S proteasome regulatory subunit), PGLS (6-phosphogluconolactonase, pentose phosphate pathway), BACE2 (beta-secretase 2), COPS9 (COP9 signalosome subunit, protein degradation), RFXANK (regulatory factor X, MHC class II transcription), NT5C (5'-nucleotidase). The module is upregulated in inflammation and reverses in remission. TP53I3 and SEM1/COPS9 suggest p53-mediated stress and proteasomal regulation. The module is heterogeneous but the inflammation-responsive pattern with TP53I3 as top hub suggests a p53-mediated stress/damage response.
Genes
BACE2, COPS9, NT5C, OST4, PDLIM1, PGLS, POLR2L, RFXANK, SEM1, TP53I3
Most correlated modules
- Redox Stress Response · correlation 0.94
- Mitochondrial Oxidative Stress · correlation 0.90
- Respiratory Chain Complex · correlation 0.89
- ER Protein Processing · correlation 0.88
- Inflammatory EC Activation · correlation 0.85
- Oxidative Phosphorylation · correlation 0.85
- Inflammatory Endothelial Activation · correlation 0.84
- Lysosomal Autophagy Program · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.