PDLIM1 — PDZ and LIM domain 1

PDLIM1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PDLIM1's module in each cell type

Cell type	Module	Shares the module with
Endothelial	p53 Stress Response Stress	BACE2, COPS9, NT5C, OST4, PGLS, POLR2L, RFXANK, SEM1 +1 more	View in SCUBA
Enterocytes	Surface colonocyte differentiation Epithelial development	AGR3, ATP1B1, BMP3, CLDN3, DSP, KLF5, KRT20, NEURL1B +2 more	View in SCUBA
Fibroblasts	IL-1 Receptor Signaling Inflammatory	CHIC2, GNAI1, IL1R1, MMD, PRR16, SMIM3, ST3GAL1, TUSC3	View in SCUBA
Goblet cells	Epithelial Membrane Identity Epithelial development	EIF3H, EPCAM, ITM2B, RAC1, SLC25A3, TMEM176A, TMEM176B, TMEM59 +1 more	View in SCUBA
Natural Killer cells	NK Maturation Program Differentiation	ARPC5L, BAALC, CDHR1, EOMES, PDE7A, S100PBP, SH2D1A, TESC +2 more	View in SCUBA
Pericytes	ER Stress Response Stress	ARF4, HSPA5, LDHA, RAP1B, REXO2, SEC61G, SELENOS, SNX6	View in SCUBA
Smooth muscle cells	Pericyte Basement Membrane ECM remodeling	ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, CSPG4, ENTPD1, HIP1 +7 more	View in SCUBA

About the gene

Synonyms	CLIM1, CLP-36, CLP36, hCLIM1
Chromosome	10: 95237572-95291012
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins

Function

Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.