RNFT1 — Ring finger protein, transmembrane 1
RNFT1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNFT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | SR Kinase & RNA RNA processing & translation | ADHFE1, ATF2, BCAP31, C4orf3, CCPG1, CHKB, CLK2, EFR3A +17 more | |
| Macrophages | Transcriptional Elongation Housekeeping | AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EIF5 +19 more | View in SCUBA |
About the gene
| Synonyms | PTD016 |
|---|---|
| Chromosome | 17: 59952240-59964761 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.