AKIRIN1 — Akirin 1
AKIRIN1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AKIRIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Autophagy Stress Response Stress | BRD9, CDKN2AIP, DHX36, DNAJB2, FOXO3, MLXIP, ODF2L, PPP2R2A +11 more | |
| Innate lymphoid cells | Transcriptional Activation DNA regulation & transcription | CHORDC1, FAM133B, FAM53C, GOLGB1, GTF2B, IDI1, MORF4L2, NABP1 +9 more | View in SCUBA |
| Macrophages | Transcriptional Elongation Housekeeping | ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EIF5, EPM2AIP1 +19 more | View in SCUBA |
| Natural Killer cells | NK Cell Activation activation | AKAP9, ALG13, DDX24, EIF1AX, ETF1, EZR, GNL3, PPP1CB +2 more | View in SCUBA |
About the gene
| Synonyms | C1orf108, FLJ12666 |
|---|---|
| Chromosome | 1: 38991276-39006059 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.