Transcriptional Elongation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 28 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZBTB7A (myeloid transcription factor, represses pro-inflammatory genes), CDK9 (P-TEFb kinase, transcription elongation), TAF7 (TFIID subunit, general transcription), ATF4 (integrated stress response TF), EIF5 (translation initiation factor 5), ZNF24 (zinc finger TF). Supporting genes include GOLGA2 (Golgi matrix), HGS (ESCRT-0, endosomal sorting), AKIRIN1 (NF-κB cofactor). The dominant theme is transcriptional regulation, particularly involving CDK9-mediated elongation and ZBTB7A-driven myeloid gene control. ATF4 adds a stress-responsive transcription component. This module likely reflects basal transcriptional machinery activity in mono_mac.
Genes
AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EIF5, EPM2AIP1, GOLGA2, HGS, KMT2B, LACTB, MAP7D1, MTMR9, N4BP2, NFATC2IP, NKIRAS2, PHF1, RNFT1, SLC4A2, TAF7, TMF1, TOLLIP, ZBTB7A, ZNF24, ZNF655, ZSWIM8
Most correlated modules
- Golgi-Endosome Trafficking · correlation 0.97
- Pre-mRNA Splicing · correlation 0.95
- Lipid-Sensing Transcriptional · correlation 0.94
- RNA Splicing Regulation · correlation 0.94
- mRNA Splicing Processing · correlation 0.93
- RNA Processing Regulation · correlation 0.93
- ER Protein Translocation · correlation 0.93
- Macrophage Endocytic Signaling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.