CHMP1A — Charged multivesicular body protein 1A
CHMP1A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHMP1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Oxidative phosphorylation Mitochondrial & OxPhos | ACADVL, COX14, EIF2AK1, EML2, ETFA, GPR108, NDUFA8, PARP1 +12 more | View in SCUBA |
| Gamma-delta T cells | Endosomal Vesicle Trafficking Housekeeping | ADRM1, CDK2AP2, COA6, CYB5B, ELOVL1, GNG5, HADHB, ICMT +11 more | |
| Macrophages | Transcriptional Elongation Housekeeping | AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CLCN7, EIF5, EPM2AIP1 +19 more | View in SCUBA |
About the gene
| Synonyms | CHMP1, KIAA0047, PCOLN3, PRSM1, Vps46A |
|---|---|
| Chromosome | 16: 89640816-89657738 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Cell cycle, Cell division, Protein transport, Transcription, Transcription regulation, Transport |
Function
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.