EIF5 — Eukaryotic translation initiation factor 5

EIF5 belongs to a gene co-expression module in 12 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EIF5's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6 +13 more	View in SCUBA
CD4⁺ T cells	mRNA Splicing Processing RNA processing	ANXA2R, APOL3, BTN3A1, CCNL1, CHCHD7, CMPK1, DDX5, EIF4A2 +7 more	View in SCUBA
CD8⁺ T cells	Immediate Early Response Stress	ARRDC3, ATF3, CLK1, EIF4A2, GADD45B, IER5, JUN, KLF6 +6 more	View in SCUBA
Fibroblasts	Integrated Stress Response Stress	ATF4, BAIAP2, DNAJB6, EIF4A3, FSCN1, HSP90AB1, HSPD1, HSPE1 +9 more	View in SCUBA
Gamma-delta T cells	ER Proteotoxic Stress Stress	ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EXOSC6, FOSB, HSPA5 +13 more
Glial cells	Proteostasis Stress Response Stress	DNAJB6, HNRNPA0, NUDT4, RSRC2, SQSTM1, TRIM8, UBE2D3, ZC3HAV1	View in SCUBA
Goblet cells	Heat Shock Response Stress	DNAJA1, EIF1AX, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPB1 +5 more	View in SCUBA
Innate lymphoid cells	Immediate Early Response activation	ATF3, BRD2, BTG2, CCNL1, DDX3X, DNAJA1, EGR1, EIF4A3 +8 more	View in SCUBA
Macrophages	Transcriptional Elongation Housekeeping	AKIRIN1, ATF4, ATXN2L, CCDC82, CDK9, CHMP1A, CLCN7, EPM2AIP1 +19 more	View in SCUBA
Mucosal-associated invariant T cell	Integrated Stress Response Stress	ATF4, EIF4A3, FAM53C, IFRD1, MARCKSL1, MKNK2, ODC1, PLK2 +7 more
Natural Killer cells	ER Stress Response Stress	ARF4, CYCS, DNAJB6, EIF4A3, GADD45B, HERPUD1, SAP18, SERTAD1	View in SCUBA
Smooth muscle cells	Translation initiation/RNA-binding RNA processing & translation	BRI3, CDV3, EPC1, FAM133B, FAM53C, FUS, MAFB, PPP1R10 +2 more	View in SCUBA

About the gene

Chromosome	14: 103333544-103345025
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	GTPase activation, Initiation factor
Biological process	Protein biosynthesis

Function

Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase- activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.