RPAP2 — RNA polymerase II associated protein 2
RPAP2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RPAP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Innate Immune Activation Inflammation | ANKRD11, ATP10D, CNOT2, COA4, DOCK10, IKZF2, NIFK, PRKDC +13 more | View in SCUBA |
About the gene
| Synonyms | C1orf82, FLJ13150, Rtr1 |
|---|---|
| Chromosome | 1: 92299059-92402056 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protein phosphatase |
| Biological process | Transcription, Transcription regulation |
Function
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.