COA4 — Cytochrome c oxidase assembly factor 4 homolog
COA4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COA4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Respiratory chain assembly Mitochondrial & OxPhos | COA6, CYC1, EBNA1BP2, ERCC1, POLR2E, PRELID3B, PSMD3, VMA21 | View in SCUBA |
| Gamma-delta T cells | Mitoribosome Small Subunit Mitochondrial & OxPhos | ACADM, C14orf119, CHCHD1, COA3, COMMD8, GALK1, GEMIN6, ISCA2 +24 more | |
| Innate lymphoid cells | Innate Immune Activation Inflammation | ANKRD11, ATP10D, CNOT2, DOCK10, IKZF2, NIFK, PRKDC, PSMD11 +13 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFRP1, ARL2, ATP6V0E1, CALHM2, CCS, DBP, DENND2D, DMAC1 +15 more |
About the gene
| Synonyms | CHCHD8, CMC3, E2IG2 |
|---|---|
| Chromosome | 11: 73872667-73876901 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Putative COX assembly factor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.