Innate Immune Activation
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 22 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
This module shows significant upregulation with inflammation (delta_inflammation = 0.489, sig.) and positive treatment response. Hub genes include TLN1 (talin-1, integrin activation and focal adhesion), RNF213 (E3 ubiquitin ligase, innate immune/interferon-stimulated gene, also involved in angiogenesis), ZNF292 (transcription factor), TPR (nuclear pore scaffold), PRKDC (DNA-PKcs, DNA repair), NIFK (nucleolar protein, ribosome biogenesis), PSMD11 (proteasome subunit), DOCK10 (Rho GEF, lymphocyte migration), IKZF2 (Helios, Treg/ILC transcription factor), SRSF9 (splicing). RNF213 is notably an interferon-stimulated gene and innate immune sensor. The inflammation association, RNF213 hub position, and PRKDC (DNA damage/innate sensing) suggest an innate immune activation/stress response program. TLN1 and DOCK10 add adhesion/migration components. The module is moderately coherent with mixed membership, but the inflammation signal is the strongest feature.
Genes
ANKRD11, ATP10D, CNOT2, COA4, DOCK10, IKZF2, NIFK, PRKDC, PSMD11, RAB10, RAB2A, RNF213, RPAP2, SLC1A4, SRSF9, TLN1, TMF1, TPR, UBAC2, VOPP1, WDR82, ZNF292
Most correlated modules
- Centrosome & Scaffolding · correlation 0.92
- NK JAK3 Signaling · correlation 0.90
- Golgi RNA Processing · correlation 0.90
- RNA Chromatin Regulation · correlation 0.89
- Endosomal Trafficking · correlation 0.89
- Splicing & Transcription · correlation 0.89
- Actin Cytoskeleton Dynamics · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.