DOCK10 — Dedicator of cytokinesis 10
DOCK10 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DOCK10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Remodeling Signaling DNA/chromatin regulation | AKAP13, BPTF, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, FBXW7 +23 more | |
| Hematopoietic progenitor cells | Regulatory T-cell State Lymphcyte development | CLEC2D, CYTIP, DDIT4, GSTA4, JCHAIN, MDFIC, MEF2A, NEGR1 +9 more | |
| Innate lymphoid cells | Innate Immune Activation Inflammation | ANKRD11, ATP10D, CNOT2, COA4, IKZF2, NIFK, PRKDC, PSMD11 +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, ELMO1, EXOC4, FCHSD2, FNDC3A, FOXN3 +20 more |
About the gene
| Synonyms | KIAA0694, ZIZ3 |
|---|---|
| Chromosome | 2: 224765090-225042468 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.