IKZF2 — IKAROS family zinc finger 2
IKZF2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IKZF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Regulatory T cell Immune regulation | ACTA2, APOLD1, ATP13A3, CARD16, CD27, CD79B, DNAH8, FAM184A +7 more | View in SCUBA |
| Gamma-delta T cells | T Cell Exhaustion Exhaustion | AKAP5, AOAH, CCDC141, CD8A, CD8B, CDYL, CRTAM, CYSTM1 +20 more | |
| Hematopoietic progenitor cells | Mast Cell Progenitor Granulocyte development | CD84, CPA3, FRY, GATA2, HPGDS, NLK, REXO5, RRBP1 +2 more | |
| Innate lymphoid cells | Innate Immune Activation Inflammation | ANKRD11, ATP10D, CNOT2, COA4, DOCK10, NIFK, PRKDC, PSMD11 +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CHD9, CLCN3, DDX17 +14 more |
About the gene
| Synonyms | Helios, ZNFN1A2 |
|---|---|
| Chromosome | 2: 212999691-213152427 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Hearing, Transcription, Transcription regulation |
Function
Transcriptional regulator required for outer hair cells (OHC) maturation and, consequently, for hearing
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.