ANKRD11 — Ankyrin repeat domain containing 11
ANKRD11 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANKRD11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | mRNA splicing RNA processing | ARGLU1, CYBC1, LUC7L3, PLCG2, PNN, SON, SRRM2, TCIRG1 +1 more | View in SCUBA |
| CD4⁺ T cells | Chromatin regulation DNA/chromatin regulation | BIRC6, CNTRL, EP300, FAM118A, GOLGA4, IRF2, KAT6A, MIER1 +12 more | View in SCUBA |
| Endothelial | Actin Cytoskeletal Remodeling Cytoskeletal | ACTR2, ARPC4, CAP1, EIF4G1, FYTTD1, G3BP1, GSPT1, IPO7 +8 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10, MFSD14A +13 more | |
| Innate lymphoid cells | Innate Immune Activation Inflammation | ATP10D, CNOT2, COA4, DOCK10, IKZF2, NIFK, PRKDC, PSMD11 +13 more | View in SCUBA |
| Macrophages | Transcriptional Repression Housekeeping | AKAP8, ARIH2, BACH1, CCNT2, CDK13, CEP95, CSNK1D, FNBP4 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Repression Immune regulation | CMIP, MXI1, NR3C1, PELI2, PROSER1, RB1CC1, RCOR1, RFTN1 +7 more |
About the gene
| Synonyms | ANCO-1, ANCO1, LZ16, T13 |
|---|---|
| Chromosome | 16: 89267630-89490561 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation. Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.