SCN3A — Sodium voltage-gated channel alpha subunit 3
SCN3A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SCN3A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Lymphoid Progenitor Commitment Lymphcyte development | BASP1, CCR9, LRRC38, LSAMP, LZTFL1, MME, OSBPL3, SH3BP5 +3 more |
About the gene
| Synonyms | Nav1.3 |
|---|---|
| Chromosome | 2: 165087526-165204050 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Voltage-gated ion channels |
| Molecular function | Ion channel, Sodium channel, Voltage-gated channel |
| Biological process | Ion transport, Sodium transport, Transport |
Function
Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage- gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. In some secretory cell types, it also participates in cell excitability through membrane depolarization and regulates cells responsiveness to stimuli triggering secretion. For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose- induced insulin secretion in pancreatic endocrine cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.