LZTFL1 — Leucine zipper transcription factor like 1
LZTFL1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LZTFL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte Motility migration & adhesion | ATP2A3, HSH2D, LRP12, MYO1G, MYO9B, NBEAL2, PPARG, TBC1D31 +1 more | View in SCUBA |
| Gamma-delta T cells | Gut-homing Residence Tissue residence | ADAM28, ASB2, ATP8B4, CAPG, CCR9, CD101, CD9, DAPK2 +8 more | |
| Hematopoietic progenitor cells | Lymphoid Progenitor Commitment Lymphcyte development | BASP1, CCR9, LRRC38, LSAMP, MME, OSBPL3, SCN3A, SH3BP5 +3 more | |
| Mucosal-associated invariant T cell | Tissue Residency Tissue residence | ACSL1, AMFR, CRACDL, DHX36, HES4, IRF8, ITGAE, MACO1 +8 more | |
| Natural Killer cells | Mature NK Identity Differentiation | ABCB1, ADAM28, ADGRG3, CCDC141, CD160, CMTM7, DZIP3, IKZF3 +5 more | View in SCUBA |
About the gene
| Synonyms | BBS17 |
|---|---|
| Chromosome | 3: 45823316-45916042 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.