SERTAD3 — SERTA domain containing 3
SERTAD3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERTAD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Dissociation Stress Artifact Technical artifact | BTG2, DNAJA4, DNAJB1, EGR1, EIF4A3, EIF5, FOS, FOSB +18 more | View in SCUBA |
About the gene
| Synonyms | RBT1 |
|---|---|
| Chromosome | 19: 40440844-40444335 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Transcription, Transcription regulation |
Function
Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms. Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex. Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation. Strong transcriptional coactivator.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.