FOS — Fos proto-oncogene, AP-1 transcription factor subunit

FOS belongs to a gene co-expression module in 17 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FOS's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	AP-1 Immediate Early BCR/AP1/NFKb pathway	BTG2, CD69, CD83, DUSP1, EIF1, FOSB, JUN, JUNB +7 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, DUSP1, EGR1, FOSB, IER2, IER5 +6 more	View in SCUBA
CD8⁺ T cells	AP-1 Early Activation TCR Signaling	BTG2, CD69, EGR1, FOSB, IER2, JUNB, LEPROTL1, LITAF +5 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DNAJB1, DUSP1, EGR1, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B +11 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3 +15 more
Glial cells	Immediate Early Gene Response Activation	DNAJB1, EGR1, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B, IER2 +3 more	View in SCUBA
Goblet cells	Immediate Early Gene chromatin regulation & transcription	BTG2, DUSP1, EGR1, FOSB, IER2, JUN, JUNB, JUND	View in SCUBA
Hematopoietic progenitor cells	Glucocorticoid Response Inflammatory	ARL4C, CYTH1, EMP1, ETS1, KLF6, LRRFIP1, PDE4B, PTPRC +4 more
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, ICAM1 +26 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	DUSP1, EGR1, FOSB, HES1, HSPA8, IER2, JUN, JUNB +7 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	AP-1 Inflammatory Activation Inflammatory	COQ7, DUSP1, IER2, JUN, JUNB, KCNE1, KLF6, NAIP +2 more	View in SCUBA
Mucosal-associated invariant T cell	Dissociation Stress Response Stress	DUSP1, EIF1, H3-3B, IER5, SAT1, SRSF3, SRSF7
Natural Killer cells	AP-1 Immediate Early activation	BTG1, CITED2, CXCR4, DUSP1, DUSP2, JUN, JUNB, KLF6 +1 more	View in SCUBA
Neutrophils	Immediate Early Response Stress	ADM, BTG2, DUSP1, EGR1, IER2, JUNB, ZFP36
Pericytes	Immediate Early Gene Stress	DNAJB1, EGR1, FOSB, HSPA1A, HSPA1B, IER2, JUN, JUNB +3 more	View in SCUBA
Smooth muscle cells	Immediate Early Response Stress	ATF3, BTG1, BTG2, CDKN1A, EGR1, GADD45B, HES1, IER2 +7 more	View in SCUBA

About the gene

Synonyms	AP-1, c-fos
Chromosome	14: 75278826-75282230
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding

Function

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.