DNAJB1 — DnaJ heat shock protein family (Hsp40) member B1

DNAJB1 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DNAJB1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB4, DNAJB6, EIF5 +13 more	View in SCUBA
CD4⁺ T cells	Heat Shock Response Stress	ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB4, HSP90AA1, HSP90AB1 +12 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	DNAJA4, DNAJB4, HSPA1A, HSPA1B, HSPA6, HSPB1, PLIN2, RGS2 +3 more	View in SCUBA
Endothelial	Shear Stress Response Stress	DUSP1, EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B +11 more	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB4, HSP90AA1 +13 more
Glial cells	Immediate Early Gene Response Activation	EGR1, FOS, FOSB, HES1, HSP90AA1, HSPA1A, HSPA1B, IER2 +3 more	View in SCUBA
Innate lymphoid cells	Heat Shock Response Stress	AHSA1, ANKRD37, DEDD2, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B +9 more	View in SCUBA
Lymphatic endothelial	Heat Shock Response Stress	BAG3, DNAJB4, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPB1, HSPE1 +3 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB4, DUSP1 +39 more	View in SCUBA
Monocytes	Heat Shock Response Stress	CHORDC1, DNAJA1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8, HSPD1 +4 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	ANKRD37, HSP90AA1, HSP90AB1, HSPA8, JUND, RGS2, UBB, UBC
Natural Killer cells	Inducible HSP70 Stress Stress	BAG3, FKBP4, HSPA1A, HSPA1B, HSPA4, HSPA6, HSPB1, RHOB +2 more	View in SCUBA
Pericytes	Immediate Early Gene Stress	EGR1, FOS, FOSB, HSPA1A, HSPA1B, IER2, JUN, JUNB +3 more	View in SCUBA
Smooth muscle cells	Heat Shock Response Stress	C12orf65, CEMIP2, CHORDC1, DNAJA1, FOSB, H2AFX, HSP90AA1, HSPA1A +8 more	View in SCUBA

About the gene

Synonyms	Hsp40, HSPF1, RSPH16B, Sis1
Chromosome	19: 14514769-14560391
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Molecular function	Chaperone
Biological process	Stress response

Function

Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.