SETDB2 — SET domain bifurcated histone lysine methyltransferase 2
SETDB2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SETDB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | MHC II Antigen Presentation Innate immunity | ARHGEF10L, CD4, CD74, HLA-DQA2, HLA-DRB5, RASA4, RTN1, SASH1 | View in SCUBA |
About the gene
| Synonyms | C13orf4, CLLD8, CLLL8, KMT1F |
|---|---|
| Chromosome | 13: 49444274-49495003 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Developmental protein, Methyltransferase, Transferase |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.