SASH1 — SAM and SH3 domain containing 1
SASH1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SASH1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | ECM Homeostatic Regulation ECM remodeling | BPTF, KCTD12, MAPRE2, OAF, ST3GAL6, TIMP2, TTC3 | View in SCUBA |
| Macrophages | ER Stress Response Stress | ARHGEF12, ATXN7, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERN1 +14 more | View in SCUBA |
| Monocytes | MHC II Antigen Presentation Innate immunity | ARHGEF10L, CD4, CD74, HLA-DQA2, HLA-DRB5, RASA4, RTN1, SETDB2 | View in SCUBA |
| Pericytes | Pericyte Vascular Identity Developmental | AHR, ARHGAP29, CA4, CD46, MEF2C, MYO6, NOTCH1, PDE1C +10 more | View in SCUBA |
About the gene
| Synonyms | dJ323M4.1, KIAA0790, SH3D6A |
|---|---|
| Chromosome | 6: 148272304-148552044 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.