SLC7A2 — Solute carrier family 7 member 2
SLC7A2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC7A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Contractile SMC Identity Contractility | C11orf96, CPE, FHL5, MAP7D3, NFIB, PTGIR, SOD3, SORBS3 | View in SCUBA |
About the gene
| Synonyms | ATRC2, CAT-2, HCAT2 |
|---|---|
| Chromosome | 8: 17497088-17570573 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins, Transporters |
| Biological process | Amino-acid transport, Transport |
Function
Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L- homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing. May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity). Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L- ornithine and L-homoarginine). Shows a much higher affinity for L- arginine and L-homoarginine than isoform 2. Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L- arginine, L-lysine, L-ornithine and L-homoarginine)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.