PTGIR — Prostaglandin I2 receptor
PTGIR belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTGIR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | LAYN+ tissue Treg Immune regulation | BEX3, CADM1, CHRNA6, EPHX2, FLVCR2, GNG8, IKZF4, LAPTM4B +7 more | View in SCUBA |
| Pericytes | Pericyte Vascular Tone Developmental | ADAP2, CHCHD10, CSPG4, FOXS1, LINGO1, MCAM, MFGE8, PGF +3 more | View in SCUBA |
| Smooth muscle cells | Contractile SMC Identity Contractility | C11orf96, CPE, FHL5, MAP7D3, NFIB, SLC7A2, SOD3, SORBS3 | View in SCUBA |
About the gene
| Synonyms | IP |
|---|---|
| Chromosome | 19: 46620468-46625089 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.