Contractile SMC Identity
Gene co-expression module in Smooth muscle cells
| Category | Contractility |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Core hubs are markers of the differentiated, contractile mural/SMC phenotype: FHL5 (myocardin/SRF co-activator of SMC contractile genes), C11orf96 (SMC-enriched regulator of contractility), PTGIR (prostacyclin receptor, vasorelaxation), SOD3 (vascular extracellular SOD), SORBS3/vinexin (actin-adhesion linkage), CPE and SLC7A2 (arginine transport for NO/polyamine metabolism), NFIB (mesenchymal TF). Together this reads as a mature contractile smooth-muscle identity/tone-regulating module, complementing the calcium-handling neighbor M77.
Genes
C11orf96, CPE, FHL5, MAP7D3, NFIB, PTGIR, SLC7A2, SOD3, SORBS3
Most correlated modules
- Pericyte Notch Identity · correlation 0.82
- Calcium Handling · correlation 0.82
- Vascular SMC Identity · correlation 0.81
- Glucocorticoid Metallothionein Response · correlation 0.78
- Mural/Pericyte Identity · correlation 0.78
- Oxidative Muscle Metabolism · correlation 0.77
- Vasoconstrictor Signaling · correlation 0.76
- Secondary Response Genes · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.