SORBS3 — Sorbin and SH3 domain containing 3
SORBS3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SORBS3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TCR signaling TCR/AP1/NFKb pathway | ACVR1C, ADA2, ANK3, CAMK4, CHD7, GCLM, GNAO1, MPP7 +15 more | View in SCUBA |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Monocytes | Complement C1q Macrophage Innate immunity | ACP2, C1QA, C1QB, C1QC, CLIC2, DNPH1, GFRA2, ITGA9 +4 more | View in SCUBA |
| Smooth muscle cells | Contractile SMC Identity Contractility | C11orf96, CPE, FHL5, MAP7D3, NFIB, PTGIR, SLC7A2, SOD3 | View in SCUBA |
About the gene
| Synonyms | SCAM-1, SH3D4, vinexin |
|---|---|
| Chromosome | 8: 22544986-22575788 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Biological process | Cell adhesion |
Function
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.