CPE — Carboxypeptidase E
CPE belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CPE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent EC Identity Endothelial cell development | ADGRG6, BCAT1, C3orf80, CELF2, KLF8, KLK10, LYST, PCDH19 +5 more | View in SCUBA |
| Pericytes | Quiescent Pericyte State Developmental | ARID5B, C1QTNF1, HOPX, ITGA7, LPP, MT2A, MTHFD2, SLIT3 +1 more | View in SCUBA |
| Smooth muscle cells | Contractile SMC Identity Contractility | C11orf96, FHL5, MAP7D3, NFIB, PTGIR, SLC7A2, SOD3, SORBS3 | View in SCUBA |
About the gene
| Chromosome | 4: 165361194-165498547 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Function
Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.