NFIB — Nuclear factor I B
NFIB belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NFIB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ACVRL1, ANXA11, ATP13A2, ENG, HPCAL1, HYAL1, LDB2, MACF1 +7 more | View in SCUBA |
| Enterocytes | Serotonergic receptor signaling Secretion | HTR4, KCNQ3, LAMB1, LIMA1, NECTIN3, TBC1D32 | View in SCUBA |
| Fibroblasts | Homeostatic Stromal Identity ECM production | ADAMTSL1, ADAMTSL3, EPB41L2, KAZALD1, LRIG1, NUPR1, PDE5A, PLXDC1 +4 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Development Valve formation | GPM6A, LRP5, MEF2C, MPP7, NFIA, PGM5, PRKAR1B, PXN +5 more | View in SCUBA |
| Smooth muscle cells | Contractile SMC Identity Contractility | C11orf96, CPE, FHL5, MAP7D3, PTGIR, SLC7A2, SOD3, SORBS3 | View in SCUBA |
About the gene
| Synonyms | NFI-RED, NFIB2, NFIB3 |
|---|---|
| Chromosome | 9: 14081843-14398983 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | DNA replication, Transcription, Transcription regulation |
Function
Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.