SLC7A7 — Solute carrier family 7 member 7
SLC7A7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC7A7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Amino acid absorption Absorption | ACY3, DHRS7, ERICH4, LEAP2, PRAP1, SLC3A1, SLC7A9, TCN2 +2 more | View in SCUBA |
| Macrophages | Glycogen Metabolism Housekeeping | ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, DSTN, GLOD4 +24 more | View in SCUBA |
| Monocytes | Immediate Early Activation Stress | ARRDC2, GALR2, IER5L, MRPL55, MTSS1, NDUFA12, NXT1, RRAS +3 more | View in SCUBA |
| Neutrophils | Freshly infiltrated neutrophils Developmental | CCR3, DSC2, FSTL4, GABRR2, GRAMD1C, HPGD, ITPK1, KIF27 +3 more |
About the gene
| Synonyms | LPI, y+LAT-1 |
|---|---|
| Chromosome | 14: 22773222-22829820 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Amino-acid transport, Transport |
Function
Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids from inside the cells in exchange with neutral amino acids plus sodium ions and may participate in nitric oxide synthesis via the transport of L-arginine. Also mediates arginine transport in non-polarized cells, such as monocytes, and is essential for the correct function of these cells. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1 (By similarity). In vitro, Na(+) and Li(+), but also H(+), are cotransported with the neutral amino acids (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.