SCUBA

DSTN — Destrin, actin depolymerizing factor

DSTN belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DSTN's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsChromatin Regulation
DNA/chromatin regulation
BIK, GCHFR, GRHPR, HDAC1, HMGN1, IMP4, LYPLA1, METAP2 +3 moreView in SCUBA
CD4⁺ T cellsER stress UPR
Protein processing & ER
CCT2, CDK2AP2, CRELD2, DDX39A, DNAJB11, EIF5A, GPSM3, GTF3A +9 moreView in SCUBA
EndothelialOxidative Stress Response
Stress
AHR, CD151, CD59, CTTNBP2NL, FLOT2, GNB4, GNG5, HYAL2 +11 moreView in SCUBA
FibroblastsNotch Fibroblast Activation
Developmental
CORO1C, DIXDC1, FHL1, MRGPRF, PDLIM5, RBPJ, SH3BGRL, TCEAL3 +2 moreView in SCUBA
Gamma-delta T cellsEffector Cell Migration
migration & adhesion
ADAM15, ADAM8, ANXA2, APOBEC3G, CD52, CTSC, FUT11, GLIPR2 +17 more
Goblet cellsProteasome Complex
Protein processing & ER
GNG5, HSBP1, NDUFA4, PCBD1, PPP1CA, PSMA3, PSMB2, PSMB5 +1 moreView in SCUBA
Innate lymphoid cellsRNA Splicing Processing
RNA processing & translation
ATP5F1C, CHMP2A, CHMP4A, CYBA, DYNC1I2, DYNLRB1, FKBP3, LSM3 +16 moreView in SCUBA
MacrophagesGlycogen Metabolism
Housekeeping
ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, GLOD4, GPR65 +24 moreView in SCUBA
Natural Killer cellsGranulysin Cytotoxic Effector
Cytotoxicity
ARL4C, EMP3, FLNA, GNLY, S100A4, S100A6, TIMP1, VCLView in SCUBA
PericytesActin Dynamics
Cytoskeletal
ARPC1A, CCND1, EMP3, MGST3, NDUFA4, PTP4A3, S100A6View in SCUBA
Smooth muscle cellsSMC contractile apparatus
Contractility
ACTA2, ACTB, CALD1, CAV1, MYL6, MYL9, PPP1R14A, SH3BGRL +2 moreView in SCUBA

About the gene

SynonymsACTDP, ADF
Chromosome20: 17570075-17609919
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Molecular functionActin-binding

Function

Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.