Glycogen Metabolism
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 33 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
GYG1 (glycogenin, glycogen synthesis initiation) is the top hub. Supporting metabolic genes include CRLS1 (cardiolipin synthase), MFF (mitochondrial fission factor), ACADM (medium-chain acyl-CoA dehydrogenase), and SLC7A7 (amino acid transporter). GPR65 is a pH-sensing GPCR relevant to lysosomal/metabolic sensing. The module is weakly coherent and heterogeneous, but the glycogen/metabolic theme is the strongest signal. CD47 (don't-eat-me signal) and TRPV2 are peripheral. Overall this reflects a mixed housekeeping/metabolic program.
Genes
ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, DSTN, GLOD4, GPR65, GRSF1, GYG1, INTS1, KARS1, LEPROTL1, LMF2, MEAF6, MFF, MRPL42, MVP, NCLN, PAIP1, PLOD3, PNKD, PTP4A1, PUS7L, RTCA, SDHC, SHISA5, SLC7A7, SPG21, TRPV2, TSNAX, YIPF5
Most correlated modules
- ER Morphology Stress · correlation 0.96
- ER-Lysosome Trafficking · correlation 0.96
- Central Carbon Metabolism · correlation 0.96
- Glycolytic Metabolism · correlation 0.96
- ER Protein Quality Control · correlation 0.95
- Actin Cytoskeleton Organization · correlation 0.95
- Oxidative Metabolic Program · correlation 0.94
- Nuclear Pore Transport · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.