SLFN11 — Schlafen family member 11
SLFN11 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLFN11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular EC Identity Endothelial cell development | AMOTL1, ARFGEF3, ATN1, CAMK1D, CASP10, CCNY, CFLAR, F11R +13 more | View in SCUBA |
About the gene
| Synonyms | FLJ34922 |
|---|---|
| Chromosome | 17: 35350305-35373701 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Endonuclease, Helicase, Hydrolase, Nuclease, RNA-binding, tRNA-binding |
| Biological process | Antiviral defense, DNA damage, Immunity |
Function
Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling. Antiviral restriction factor with manganese- dependent type II tRNA endoribonuclease. A single tRNA molecule is bound and cleaved by the SLFN11 dimer. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses. Exploits the unique viral codon bias towards A/T nucleotides. Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.