ATN1 — Atrophin 1
ATN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular EC Identity Endothelial cell development | AMOTL1, ARFGEF3, CAMK1D, CASP10, CCNY, CFLAR, F11R, FGD5 +13 more | View in SCUBA |
| Gamma-delta T cells | Transcriptional Coactivation DNA/chromatin regulation | ATP13A3, ATP1A1, CREBBP, FAM76B, GAK, GALNT1, MDM2, PDS5A +12 more |
About the gene
| Synonyms | B37, D12S755E, DRPLA |
|---|---|
| Chromosome | 12: 6924463-6942321 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.