CAMK1D — Calcium/calmodulin dependent protein kinase ID
CAMK1D belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAMK1D's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Membrane adhesion remodeling migration & adhesion | ARL6IP5, ATP6V0E1, CAST, CELF2, DDAH2, EMP3, FLNA, FXYD5 +6 more | View in SCUBA |
| Endothelial | Vascular EC Identity Endothelial cell development | AMOTL1, ARFGEF3, ATN1, CASP10, CCNY, CFLAR, F11R, FGD5 +13 more | View in SCUBA |
| Enterocytes | Crypt antimicrobial progenitor Antibacterial | CHRM3, DIAPH2, EMP2, HES1, IFITM2, LYZ, PTPN13, SULF2 | View in SCUBA |
| Gamma-delta T cells | Naive T cell quiescence T cell maturation | ADAP1, ARL4C, BCL9L, BMAL1, CALM1, CD44, CD5, CD6 +10 more | |
| Goblet cells | Colonocyte Differentiation Program Epithelial development | ASCL2, CDK6, EDIL3, ENTPD5, FOXN3, HMGCS2, IRF2BP2, KLF5 +8 more | View in SCUBA |
| Macrophages | Endosomal Rab Trafficking Vesicular traficking | ABL1, ANKS1A, ARB2A, CPEB3, DENND4C, DISC1, FBXL17, FTO +15 more | View in SCUBA |
| Monocytes | Non-classical Monocyte State Tissue adaptation | CTSC, FAM162A, MS4A7, NBDY, SLC25A33, SLC3A2, TUBA1B, TUBB | View in SCUBA |
About the gene
| Synonyms | CKLiK |
|---|---|
| Chromosome | 10: 12349547-12835545 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Allosteric enzyme, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Inflammatory response, Neurogenesis |
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.