Vascular EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes FGD5 and TEK (Tie2) are canonical arterial/venous endothelial identity markers. TEK encodes the angiopoietin receptor critical for vascular homeostasis. FGD5 is a Rho-GEF expressed in quiescent endothelium. Supporting genes include OSMR (cytokine receptor), AMOTL1 (angiomotin-like, junctional polarity), HOXB7 (vascular HOX transcription factor), CAMK1D (calcium signaling), CFLAR (apoptosis regulator in endothelium), GNAQ (G-protein signaling), and SERINC1/3 (serine incorporator lipid metabolism). The module is downregulated in inflammation and partially restored in remission, consistent with a quiescent endothelial identity program. Neighbor context: this module sits near M29 which also marks quiescent/homeostatic endothelial state, reinforcing the interpretation of a baseline vascular identity program.
Genes
AMOTL1, ARFGEF3, ATN1, CAMK1D, CASP10, CCNY, CFLAR, F11R, FGD5, FNBP1, GNAQ, HOXB7, MAP3K11, NHSL2, OSMR, PURA, SERINC1, SERINC3, SLC44A1, SLFN11, TEK, WNK1
Most correlated modules
- EC Quiescence Identity · correlation 0.87
- Hypoxia-IFN Endothelial · correlation 0.81
- Endothelial Barrier Homeostasis · correlation 0.80
- WAVE Complex Cytoskeleton · correlation 0.78
- Cytoskeletal Scaffolding · correlation 0.77
- EC Barrier Integrity · correlation 0.77
- NF-kB Chromatin Regulation · correlation 0.75
- Chromatin Cell Cycle · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.